Angelica acutiloba is a plant of the Umbelliferae family, and its dried roots are used as crude drugs. It has been reported that its roots has Angiotensin Ⅰ converting enzyme (ACE) inhibitory activity, which is an index of high blood pressure inhibitory activity1). Ohno et al. have already reported that ACE nhibitory activity is also present in the leaves and stems that were previously unused and discarded2). However, it is unclear what kind of substance the ACE inhibitory activity contained in Angelica acutiloba is derived from. Therefore, in this study, component analysis was performed for the purpose of clarifying the substances involved in ACE inhibitory activity from the leaves of Angelica acutiloba produced in Yamaguchi prefecture. As a result, we consider that the ACE inhibitory active substance in the leaves of Angelica acutiloba produced there is nicotianamine.
